Abstract
d-chiro-inositol (DCI) and manganese were administered orally singly and together to streptozotocin (STZ)- induced diabetic rats for 21 days and blood glucose values and body weights determined. At blood glucose values above 500 mg/dL, values were unchanged with DCI, manganese sulfate, or both over ten days. Insulin was administered to reduce the hyperglycemia to approximately 300 mg/dL. Over 12 days, DCI alone significantly reduced blood glucose (23%), and the combination of DCI and manganese sulfate reduced hyperglycemia even more effectively (40%) as compared to control animals. Of further interest, body weights both of female and male rats administered DCI and manganese were reduced, with females 25% compared to controls and males 21% compared to controls over the 21-day period. Metabolic mechanisms of actions of DCI and manganese to explain these results are discussed.
Keywords: d-chiro-inositol, chronic administration, type 2 diabetes, hyperglycemia, manganese
Current Bioactive Compounds
Title: Synergistic Effects of d-Chiro-Inositol and Manganese on Blood Glucose and Body Weight of Streptozotocin-Induced Diabetic Rats
Volume: 6 Issue: 2
Author(s): Gilbert Gluck, Tatiana Anguelova, Douglas Heimark and Joseph Larner
Affiliation:
Keywords: d-chiro-inositol, chronic administration, type 2 diabetes, hyperglycemia, manganese
Abstract: d-chiro-inositol (DCI) and manganese were administered orally singly and together to streptozotocin (STZ)- induced diabetic rats for 21 days and blood glucose values and body weights determined. At blood glucose values above 500 mg/dL, values were unchanged with DCI, manganese sulfate, or both over ten days. Insulin was administered to reduce the hyperglycemia to approximately 300 mg/dL. Over 12 days, DCI alone significantly reduced blood glucose (23%), and the combination of DCI and manganese sulfate reduced hyperglycemia even more effectively (40%) as compared to control animals. Of further interest, body weights both of female and male rats administered DCI and manganese were reduced, with females 25% compared to controls and males 21% compared to controls over the 21-day period. Metabolic mechanisms of actions of DCI and manganese to explain these results are discussed.
Export Options
About this article
Cite this article as:
Gluck Gilbert, Anguelova Tatiana, Heimark Douglas and Larner Joseph, Synergistic Effects of d-Chiro-Inositol and Manganese on Blood Glucose and Body Weight of Streptozotocin-Induced Diabetic Rats, Current Bioactive Compounds 2010; 6 (2) . https://dx.doi.org/10.2174/157340710791184831
DOI https://dx.doi.org/10.2174/157340710791184831 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
High Throughput Study for Molecular Mechanism of Metformin
Pre-Diabetic Protection <i>via</i> Microarray Approach
Endocrine, Metabolic & Immune Disorders - Drug Targets Regulatory T-Cells: Immunomodulators in Health and Disease
Current Topics in Medicinal Chemistry Role of Adipokines and Cytokines in Non-alcoholic Fatty Liver Disease
Reviews on Recent Clinical Trials Emerging Advances in Nanomedicine as a Nanoscale Pharmacotherapy in Rheumatoid Arthritis: State of the Art
Current Topics in Medicinal Chemistry The Use of Infliximab in Dermatology
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Osteoprotegerin and Diabetes-Associated Pathologies
Current Molecular Medicine Editorial: Emerging Pharmacological Strategies for the Prevention of Atherosclerotic Disease Progression
Current Drug Targets - Cardiovascular & Hematological Disorders Pyridoxamine, an Inhibitor of Advanced Glycation End Product (AGE) Formation Ameliorates Insulin Resistance in Obese, Type 2 Diabetic Mice
Protein & Peptide Letters Use of Biguanides and the Risk of Colorectal Cancer: A Register-Based Cohort Study
Current Drug Safety Atheromatosis Extent in Coronary Artery Disease is not Correlated with Apolipoprotein-E Polymorphism and its Plasma Levels, but Associated with Cognitive Decline
Current Alzheimer Research Medicinal Chemistry of Drugs Used in Diabetic Cardiomyopathy
Current Medicinal Chemistry Natural Products Modulating Autophagy Pathway Against the Pathogenesis of Diabetes Mellitus
Current Drug Targets Cross-Talk Between Adipose Tissue Health, Myocardial Metabolism and Vascular Function: The Adipose-Myocardial and Adipose-Vascular Axes
Current Pharmaceutical Design Immunomodulatory Actions of Vitamin D Metabolites and their Potential Relevance to Human Lung Disease
Current Respiratory Medicine Reviews Ambulatory Blood Pressure Monitoring in the Diagnosis and Management of Arterial Hypertension in Current Medical Practice in Algeria
Current Hypertension Reviews Modulation of Energy Intake and Expenditure Due to Habitual Physical Exercise
Current Pharmaceutical Design Herbal Medicine of the 21st Century: A Focus on the Chemistry, Pharmacokinetics and Toxicity of Five Widely Advocated Phytotherapies
Current Topics in Medicinal Chemistry A Systematic Review of a Naturally Occurring Iridoid: Catalpol
Current Bioactive Compounds Relationships of Beta2- and Beta3--Adrenoceptor Polymorphisms with Obesity, Hypertension and Metabolic Syndrome
Current Hypertension Reviews The Menstrual Cycle and Drug Metabolism
Current Drug Metabolism