The Heat Shock Connection of Metabolic Stress and Dietary Restriction

Author(s): Balazs Dancso, Zoltan Spiro, Mehmet Alper Arslan, Minh Tu Nguyen, Diana Papp, Peter Csermely, Csaba Soti

Journal Name: Current Pharmaceutical Biotechnology

Volume 11 , Issue 2 , 2010

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Molecular chaperones and the heat shock response guard and modulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellar networks. Overnutrition and the metabolic syndrome represent a pro-aging condition, and dietary restriction is the most robust environmental intervention that induces longevity from yeast to mammals. In recent years a considerable effort has been made to elucidate the signaling pathways involved in metabolic signaling. Here we review the current understanding on the connection between metabolic stress, dietary restriction and the heat shock response and highlight results showing chaperone induction as a promising therapeutic strategy to promote healthy aging and to prevent metabolic disorders.

Keywords: Aging, caloric restriction, diabetes, heat shock response, resveratrol, sirtuin

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Article Details

Year: 2010
Page: [139 - 145]
Pages: 7
DOI: 10.2174/138920110790909704
Price: $65

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