Abstract
Recent studies have suggested that a specific small population of cells termed tumor-initiating cells (TICs) may be intrinsically resistant to therapy including radiation, and may therefore be the primary mediators of recurrence. Numerous targets are being explored using multiple approaches for their involvement in the self-renewal or survival as well as radioresistance of breast TICs. These studies will provide a broad range of compounds to be tested and to develop novel TIC radiosensitizers that will improve clinical outcome and decrease recurrence of cancer after radiation. In this review we will discuss recent efforts to identify and target these cells to selectively radiosensitize them with novel agents, as well as the TIC radiosensitizing potential of current therapies already in clinical use.
Keywords: Breast cancer, Radiation, Cancer stem cells, Tumor-initiating cells
Anti-Cancer Agents in Medicinal Chemistry
Title: Potential Targets for Improving Radiosensitivity of Breast Tumor-Initiating Cells
Volume: 10 Issue: 2
Author(s): Wei Xu, Bisrat G. Debeb, Lara Lacerd and Wendy A. Woodward
Affiliation:
Keywords: Breast cancer, Radiation, Cancer stem cells, Tumor-initiating cells
Abstract: Recent studies have suggested that a specific small population of cells termed tumor-initiating cells (TICs) may be intrinsically resistant to therapy including radiation, and may therefore be the primary mediators of recurrence. Numerous targets are being explored using multiple approaches for their involvement in the self-renewal or survival as well as radioresistance of breast TICs. These studies will provide a broad range of compounds to be tested and to develop novel TIC radiosensitizers that will improve clinical outcome and decrease recurrence of cancer after radiation. In this review we will discuss recent efforts to identify and target these cells to selectively radiosensitize them with novel agents, as well as the TIC radiosensitizing potential of current therapies already in clinical use.
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Cite this article as:
Xu Wei, Debeb G. Bisrat, Lacerd Lara and Woodward A. Wendy, Potential Targets for Improving Radiosensitivity of Breast Tumor-Initiating Cells, Anti-Cancer Agents in Medicinal Chemistry 2010; 10 (2) . https://dx.doi.org/10.2174/187152010790909362
DOI https://dx.doi.org/10.2174/187152010790909362 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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