General Anesthetic Actions on GABAA Receptors

Author(s): Paul S. Garcia, Scott E. Kolesky, Andrew Jenkins

Journal Name: Current Neuropharmacology

Volume 8 , Issue 1 , 2010

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General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABAA receptor. In this review we will discuss what is known about anesthetic – GABAA receptor interactions.

Keywords: GABAA Receptor, General Anesthetic, Isoflurane, Desflurane, Sevoflurane, Propofol, Etomidate, Barbiturates

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Article Details

Year: 2010
Page: [2 - 9]
Pages: 8
DOI: 10.2174/157015910790909502

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