Cholinesterase Interactions with Oximes

Author(s): Z. Kovarik, M. Katalinic, A. Bosak, G. Sinko

Journal Name: Current Bioactive Compounds

Volume 6 , Issue 1 , 2010


Become EABM
Become Reviewer
Call for Editor

Abstract:

The phosphorylation of the serine hydroxyl group in the active site of acetylcholinesterase (AChE) inactivates this essential enzyme in neurotransmission. Oximes are reactivators of AChE phosphorylated by organophosphorus compounds (OP) including insecticides and nerve agents. The effectiveness of oxime-assisted reactivation is primarily attributed to the nucleophilic displacement rate of organophosphate, but efficiency varies with the structure of the bound

Keywords: Acetylcholinesterase, antidote, bioscavenger, butyrylcholinesterase, nerve agents, tabun, oxime, treatment

promotion: free to download

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 6
ISSUE: 1
Year: 2010
Page: [9 - 15]
Pages: 7
DOI: 10.2174/157340710790711764

Article Metrics

PDF: 16