Abstract
Endothelial tight junctions (TJs) in the retina are potential therapeutic targets for diabetic complications such as retinopathy. TJs primarily determine the endothelial barrier, regulating vascular permeability to maintain tightly closed circulating homeostasis. Our recent study has demonstrated that glial cell-derived cytokines limit vascular permeability by modulating the TJ function of retinal capillary endothelium and eventually attenuate the breakdown of vascular integrity in diabetic microangiopathy. In addition, suppression of deregulated protease activity in lens cells results in dramatic inhibition of the development of murine diabetic cataracts. We believe that pharmacological modulation of the ocular tissue microenvironment such as that regulated by endothelial TJs may be a feasible strategy for reducing the development of diabetic complications in the eye.
Keywords: Tight junction, Blood-retinal barrier, Diabetes, Retinopathy, Cataract, Retinoic acid
Current Diabetes Reviews
Title: Emerging Novel Treatment Strategies for Diabetic Eye Diseases
Volume: 6 Issue: 1
Author(s): Makoto Osanai, Nami Nishikiori, Gang-Hong Lee and Norimasa Sawada
Affiliation:
Keywords: Tight junction, Blood-retinal barrier, Diabetes, Retinopathy, Cataract, Retinoic acid
Abstract: Endothelial tight junctions (TJs) in the retina are potential therapeutic targets for diabetic complications such as retinopathy. TJs primarily determine the endothelial barrier, regulating vascular permeability to maintain tightly closed circulating homeostasis. Our recent study has demonstrated that glial cell-derived cytokines limit vascular permeability by modulating the TJ function of retinal capillary endothelium and eventually attenuate the breakdown of vascular integrity in diabetic microangiopathy. In addition, suppression of deregulated protease activity in lens cells results in dramatic inhibition of the development of murine diabetic cataracts. We believe that pharmacological modulation of the ocular tissue microenvironment such as that regulated by endothelial TJs may be a feasible strategy for reducing the development of diabetic complications in the eye.
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Cite this article as:
Osanai Makoto, Nishikiori Nami, Lee Gang-Hong and Sawada Norimasa, Emerging Novel Treatment Strategies for Diabetic Eye Diseases, Current Diabetes Reviews 2010; 6 (1) . https://dx.doi.org/10.2174/157339910790442619
DOI https://dx.doi.org/10.2174/157339910790442619 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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