Abstract
The use of emerging multicomponent reactions (MCRs) in conjunction with microwave (MW)-assisted chemistry techniques is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. The MW-assisted MCRs offer rapid and efficient procedures for the introduction of many points of structural diversity into heterocyclic compounds prepared in a straightforward manner in a single synthetic step. The present review summarizes recent developments in MW-assisted MCRs for the construction of five-, six-, and seven-membered heterocyclic skeletons as well as dicyclic system. Methods for the generation of both simple and fused heterocyclic targets are described, with particular emphasis on the introduction of structural diversity and complexity. In many cases, MW-assisted MCRs offer considerable improvements in selectivity, chemical yield and purity and constitute a very simple and extremely rapid method to access a diverse range of heterocyclic motifs.
Current Organic Chemistry
Title: Microwave-Assisted Multicomponent Reactions in the Heterocyclic Chemistry
Volume: 14 Issue: 4
Author(s): Bo Jiang, Feng Shi and Shu-Jiang Tu
Affiliation:
Abstract: The use of emerging multicomponent reactions (MCRs) in conjunction with microwave (MW)-assisted chemistry techniques is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. The MW-assisted MCRs offer rapid and efficient procedures for the introduction of many points of structural diversity into heterocyclic compounds prepared in a straightforward manner in a single synthetic step. The present review summarizes recent developments in MW-assisted MCRs for the construction of five-, six-, and seven-membered heterocyclic skeletons as well as dicyclic system. Methods for the generation of both simple and fused heterocyclic targets are described, with particular emphasis on the introduction of structural diversity and complexity. In many cases, MW-assisted MCRs offer considerable improvements in selectivity, chemical yield and purity and constitute a very simple and extremely rapid method to access a diverse range of heterocyclic motifs.
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Cite this article as:
Jiang Bo, Shi Feng and Tu Shu-Jiang, Microwave-Assisted Multicomponent Reactions in the Heterocyclic Chemistry, Current Organic Chemistry 2010; 14 (4) . https://dx.doi.org/10.2174/138527210790231892
DOI https://dx.doi.org/10.2174/138527210790231892 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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