Hapten Recognition by T Cells: A Functional and Molecular View

Author(s): Alessandra Franco

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 8 , Issue 4 , 2009

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T cells specific for haptens determine immunopathology, as for the recognition of the β-lactamic ring by CD4+ T helper cells, responsible for the severe immune response to Penicillin in allergic patients. In this review we report studies that address functional and molecular aspects of hapten recognition by α/β T cells, enlightening the most relevant examples of hapten-specific T cells and their role in vivo. Using Trinitrophenyl as a contact allergen model and tumor associated carbohydrate antigens (TACA) as antigen models in cancer, our laboratory extensively studied T cell recognition by hapten-specific T cells suggesting new, unexplored avenues for T cell-based immunotherapy. In fact, the evidence of hapten recognition by “conventional” α/β T cells is of a critical importance in designing new immunotherapeutic approaches to treat allergies, cancer and chronic viral diseases.

Keywords: Haptens, drugs, metals, TACA, antigen presenting cells, T cells, immunotherapy

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Article Details

Year: 2009
Page: [366 - 376]
Pages: 11
DOI: 10.2174/187152309789839019
Price: $65

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