A Concept of Homeostatic Inflammation Provided by Endogenous TLR4 Agonists that Function Before and After Danger Signal for Metastasis

Author(s): Yoshiro Maru

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents

Volume 8 , Issue 4 , 2009

Become EABM
Become Reviewer
Call for Editor


Provoked by the discovery of metastasis-inducing endogenous ligands of TLR4 that has been recognized as a sensor for extrinsic pathogens, I propose an extended concept for danger signal that originally meant sentinels over tissue destruction by cancer. The so-called “homeostatic inflammation” concept includes signals before destruction actually takes place such as those in pre-metastatic microenvironment and possibly even in physiological conditions. It is orchestrated by tight cross-talks between growth factor and chemokine signaling.

Keywords: S100A8, SAA3, TLR4, metastasis, pre-metastasis, inflammation, homeostasis

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2009
Page: [337 - 347]
Pages: 11
DOI: 10.2174/187152309789839064
Price: $65

Article Metrics

PDF: 6