Abstract
Interest in the biomimetic properties of soft scorpionates based on methimazole commenced shortly after the reported synthesis of the hydrotris(methimazolyl)borate anion (TmMe) in 1996. These ligands are thione based and are thus not subject to facile oxidation and disulfide formation (c.f. thiolates). This allows these species to participate in an extensive coordination chemistry with a wide variety of metals. This review focuses on the chemistry of the RTmR and RBmR ligands with special reference to their use in biomimetic chemistry (alcohol dehydrogenase, Ada repair proteins, 5- aminolevulinate dehydratase, sulfite oxidase, hydrogenase, MerB) and their emerging use as radiopharmaceuticals (rhenium, technetium).
Current Bioactive Compounds
Title: The Bioinorganic Chemistry of Methimazole Based Soft Scorpionates
Volume: 5 Issue: 4
Author(s): John Reglinski and Mark D. Spicer
Affiliation:
Abstract: Interest in the biomimetic properties of soft scorpionates based on methimazole commenced shortly after the reported synthesis of the hydrotris(methimazolyl)borate anion (TmMe) in 1996. These ligands are thione based and are thus not subject to facile oxidation and disulfide formation (c.f. thiolates). This allows these species to participate in an extensive coordination chemistry with a wide variety of metals. This review focuses on the chemistry of the RTmR and RBmR ligands with special reference to their use in biomimetic chemistry (alcohol dehydrogenase, Ada repair proteins, 5- aminolevulinate dehydratase, sulfite oxidase, hydrogenase, MerB) and their emerging use as radiopharmaceuticals (rhenium, technetium).
Export Options
About this article
Cite this article as:
Reglinski John and Spicer D. Mark, The Bioinorganic Chemistry of Methimazole Based Soft Scorpionates, Current Bioactive Compounds 2009; 5 (4) . https://dx.doi.org/10.2174/157340709789816465
DOI https://dx.doi.org/10.2174/157340709789816465 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Resonant Oscillation Language of a Futuristic Nano-Machine-Module: Eliminating Cancer Cells & Alzheimer Aβ Plaques
Current Topics in Medicinal Chemistry Metabolic Profiling in Multiple Sclerosis and Other Disorders by Quantitative Analysis of Cerebrospinal Fluid Using Nuclear Magnetic Resonance Spectroscopy
Current Pharmaceutical Biotechnology Structural MRI Biomarkers of Mild Cognitive Impairment from Young Elders to Centenarians
Current Alzheimer Research ThermoTRP Channels in Nociceptors: Taking a Lead from Capsaicin Receptor TRPV1
Current Neuropharmacology Contemporary Management of Hypertension - How to Optimize Therapy
Cardiovascular & Hematological Disorders-Drug Targets Corrosion Inhibiting Evaluation of β-Cyclodextrin Functionalized Acrylamide Copolymer for X70 Steel in Sulfuricsolution
Current Analytical Chemistry Management of Obesity in Patients with Type 2 Diabetes Mellitus
Current Diabetes Reviews Regulation of Clusterin Gene Expression
Current Protein & Peptide Science Evidence that Cortical Dopamine is a Co-Transmitter in Noradrenergic Neurons
Current Psychiatry Reviews Pharmacogenetic Approach to Treating Drug Dependence: Serotonin Transporter Gene (SLC6A4) Promoter Polymorphisms as Treatment Predictors in Jordanian Arabs
Current Pharmacogenomics and Personalized Medicine Decrease in Secondary Neck Vessels in Multiple Sclerosis: A 5-year Longitudinal Magnetic Resonance Angiography Study
Current Neurovascular Research Inhibition of Sphingomyelin Hydrolysis: Targeting the Lipid Mediator Ceramide as a Key Regulator of Cellular Fate
Current Medicinal Chemistry The Effect of Liver Cirrhosis on the Regulation and Expression of Drug Metabolizing Enzymes
Current Drug Metabolism Revisiting Non-Cancer Drugs for Cancer Therapy
Current Topics in Medicinal Chemistry Meet Our Editorial Board Member:
Central Nervous System Agents in Medicinal Chemistry Positron Emission Tomography: Applications In Drug Discovery and Drug Development
Current Topics in Medicinal Chemistry Melatonin in the Biliary Tract and Liver: Health Implications
Current Pharmaceutical Design 5-HT2A Inverse-Agonists for the Treatment of Insomnia
Current Topics in Medicinal Chemistry Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders
Current Alzheimer Research Pharmacotherapy of Down’s Syndrome: When and Which?
CNS & Neurological Disorders - Drug Targets