Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes

Author(s): Juan F. Vera, Malcolm K. Brenner, Gianpietro Dotti

Journal Name: Current Gene Therapy

Volume 9 , Issue 5 , 2009

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Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.

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Article Details

Year: 2009
Page: [396 - 408]
Pages: 13
DOI: 10.2174/156652309789753338
Price: $65

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