Targeting Prostate Cancer Stem Cells

Author(s): Francesco Crea, Lesley A. Mathews, William L. Farrar, Elaine M. Hurt

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 9 , Issue 10 , 2009

Become EABM
Become Reviewer
Call for Editor


Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.

Keywords: Prostate, cancer stem cells, tumor-initiating cells, molecular therapies, transforming growth factor beta, hedgehog, notch, betacatenin

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2009
Page: [1105 - 1113]
Pages: 9
DOI: 10.2174/187152009789735053
Price: $65

Article Metrics

PDF: 30