Electrochemical Behavior of Ornidazole and its Adsorptive Stripping Determination in Pharmaceuticals

Senol      Turan; Zehra      Durmus; Esma      Kilic

Abstract

The elecrochemical behavior of ornidazole was investigated using various voltammetric methods. The number of electrons transferred and diffusion coefficient were calculated by using cyclic voltammetry and bulk electrolysis techniques. It is determined that ornidazole is adsorbed on the hanging mercury drop electrode (HMDE) by using cyclic voltammetric data. Therefore, sensitive adsorptive stripping voltammetric methods for the determination of ornidazole at HMDE were developed. A systematic study of various experimental conditions was examined by using differential pulse adsorpive stripping voltammetry (DPAdsSV) and square wave adsorptive stripping voltammetry (SWAdsSV). This electroanalytical procedure enabled to determine ornidazole in the concentration range 8.0x10-7-1.0x10-5 molL-1 for both DPAdsSV and SWAdsSV. The detection and quantification limits were found to be 7.6x10-8 and 2.6x10-7 for DPAdsSV and 3.4x10-8 and 1.3x10-7 mol L-1 for SWAdsSV, respectively. The methods were applied to three different commercial pharmaceutical capsule preparations.The data obtained from commercial preparations were compared with those from a published spectrophotometric method. No difference was found statistically.

Keywords: Ornidazole, Square wave adsorptive stripping voltammetry, Differential pulse adsorptive stripping voltammetry, Hanging mercury drop electrode, Pharmaceutical dosage

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