Abstract
With the development of catalytic asymmetric methodologies directed to the synthesis of biologically active molecules during the last years, organocatalysis has emerged as a powerful tool. The organocatalytic approach is complementary to transition metal-based catalysis within the field of asymmetric synthesis and several research groups have achieved great aims in this area by the first time. The enantioselective Friedel-Crafts alkylation reaction of indoles is a powerful and direct method for preparing enantiomerically pure 3- or 2-substituted indolyl compounds and a number of organocatalyzed syntheses of these indolyl substrates have been developed in recent years. Due to the abundance of indole moieties in enantiomerically pure biologically interesting natural compounds asymmetric strategies have arisen as important processes of synthesis. These important alkylation processes including the addition of indole to α,β-unsaturated carbonyl compounds, nitroalkenes and imines as well as their applications will be discussed in this review.
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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