Abstract
Introduction: HIV-1 is regarded most responsible for a neurodegenerative disease, called HIV-associated dementia (HAD). The pathogenic trait of this severe complication of HIV-infection is still unclear, but disturbed systemic and central nervous system immune function seem to be an important component. Cytokines are important mediators of the human immune system. The review focusses on major cytokines and related immune modulators. Methods: For literature research, the PubMed library, Ovid, Cochrane database, Scirus and Google scholar were used. Results: The article discusses the importance of interferons, interleukins, chemokines, adhesion molecules, colony stimulating factors and tumor necrosis factors. Conclusion: The role of cytokines in the development to HAD is still not clear. Neither their diagnostical or therapeutical potentials nor the basic pathogenetic involvements are completely understood, but the importance of those molecules is evident.
Keywords: HIV, CNS, cytokines, interleukins, chemokines, TNF, HAD, adhesion molecules
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Cytokines in HIV-Infection - Inflammatory Damage or Therapeutic Potential?
Volume: 8 Issue: 2
Author(s): Gabriele Arendt and Thorsten Nolting
Affiliation:
Keywords: HIV, CNS, cytokines, interleukins, chemokines, TNF, HAD, adhesion molecules
Abstract: Introduction: HIV-1 is regarded most responsible for a neurodegenerative disease, called HIV-associated dementia (HAD). The pathogenic trait of this severe complication of HIV-infection is still unclear, but disturbed systemic and central nervous system immune function seem to be an important component. Cytokines are important mediators of the human immune system. The review focusses on major cytokines and related immune modulators. Methods: For literature research, the PubMed library, Ovid, Cochrane database, Scirus and Google scholar were used. Results: The article discusses the importance of interferons, interleukins, chemokines, adhesion molecules, colony stimulating factors and tumor necrosis factors. Conclusion: The role of cytokines in the development to HAD is still not clear. Neither their diagnostical or therapeutical potentials nor the basic pathogenetic involvements are completely understood, but the importance of those molecules is evident.
Export Options
About this article
Cite this article as:
Arendt Gabriele and Nolting Thorsten, Cytokines in HIV-Infection - Inflammatory Damage or Therapeutic Potential?, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2009; 8 (2) . https://dx.doi.org/10.2174/187152309789152066
DOI https://dx.doi.org/10.2174/187152309789152066 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Meet Our Editorial Board Member:
Current Alzheimer Research Music Therapy for Individuals with Dementia: Areas of Interventions and Research Perspectives
Current Alzheimer Research Meet Our Section Editor:
Current Pharmaceutical Biotechnology Tau as a Therapeutic Target for Alzheimers Disease
Current Alzheimer Research Endothelial Dysfunction, Obesity and Insulin Resistance
Current Vascular Pharmacology QSAR and Molecular Modeling Studies on a Series of Pyrrolidine Analogs Acting as BACE-1 Inhibitors
Letters in Drug Design & Discovery Patterns of Gray and White Matter Changes in Individuals at Risk for Alzheimer’s Disease
Current Alzheimer Research Clinical and Prognostic Implications of Cognitive Dysfunction and Depression in COPD
Current Respiratory Medicine Reviews An Overview of Piperazine Scaffold as Promising Nucleus for Different Therapeutic Targets
Current Pharmaceutical Design Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor
Medicinal Chemistry Thioridazine: The Good and the Bad
Recent Patents on Anti-Infective Drug Discovery Peripheral Benzodiazepine Receptor (PBR) New Insight in Cell Proliferation and Cell Differentiation Review
Current Clinical Pharmacology Central Hemodynamics in Risk Assessment Strategies: Additive Value Over and Above Brachial Blood Pressure
Current Pharmaceutical Design Shear Stress-sensitive Carriers for Localized Drug Delivery
Current Pharmaceutical Design Adrenomedullin as a Potential Therapeutic Agent for Inflammatory Bowel Disease
Current Protein & Peptide Science Interacting with γSecretase for Treating Alzheimer's Disease: From Inhibition to Modulation
Current Medicinal Chemistry The Role of Viruses in Neurodegenerative and Neurobehavioral Diseases
CNS & Neurological Disorders - Drug Targets A Perspective to the Correlation Between Brain Insulin Resistance and Alzheimer: Medicinal Chemistry Approach
Current Diabetes Reviews Glucocorticoids, the Etiology of Obesity and the Metabolic Syndrome
Current Alzheimer Research Cognitive Functions under Anti-HER2 Targeted Therapy in Cancer Patients: A Scoping Review
Endocrine, Metabolic & Immune Disorders - Drug Targets