Cytokines in HIV-Infection - Inflammatory Damage or Therapeutic Potential?

Author(s): Gabriele Arendt, Thorsten Nolting

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Volume 8 , Issue 2 , 2009

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Introduction: HIV-1 is regarded most responsible for a neurodegenerative disease, called HIV-associated dementia (HAD). The pathogenic trait of this severe complication of HIV-infection is still unclear, but disturbed systemic and central nervous system immune function seem to be an important component. Cytokines are important mediators of the human immune system. The review focusses on major cytokines and related immune modulators. Methods: For literature research, the PubMed library, Ovid, Cochrane database, Scirus and Google scholar were used. Results: The article discusses the importance of interferons, interleukins, chemokines, adhesion molecules, colony stimulating factors and tumor necrosis factors. Conclusion: The role of cytokines in the development to HAD is still not clear. Neither their diagnostical or therapeutical potentials nor the basic pathogenetic involvements are completely understood, but the importance of those molecules is evident.

Keywords: HIV, CNS, cytokines, interleukins, chemokines, TNF, HAD, adhesion molecules

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Article Details

Year: 2009
Page: [115 - 130]
Pages: 16
DOI: 10.2174/187152309789152066
Price: $65

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