Neonatal Necrotizing Enterocolitis – Inflammation and Intestinal Immaturity

Author(s): Erika C. Claud

Journal Name: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents)

Volume 8 , Issue 3 , 2009

Become EABM
Become Reviewer


Neonatal necrotizing enterocolitis is a devastating inflammatory bowel disease of premature infants. The pathogenesis remains incompletely understood and there is no specific treatment. Efforts are ongoing to understand aspects of intestinal immaturity which contribute to susceptibility to this disease. This review focuses on bacterial colonization patterns, intestinal barrier function, and inflammatory responses of immature enterocytes leading to a unique vulnerability of the preterm gut. In addition the possible therapeutic potential of factors in human milk and probiotic bacteria is discussed.

Keywords: Neonatal necrotizing enterocolitis, premature infant, probiotic, human milk, platelet activating factor, nuclear factor kappaB

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2009
Page: [248 - 259]
Pages: 12
DOI: 10.2174/187152309789152020
Price: $65

Article Metrics

PDF: 7