NK Cell Receptors and Their Interactions with MHC

Author(s): Roberto Biassoni, Elisabetta Ugolotti, Andrea De Maria

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 28 , 2009

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Abstract:

MHC-specific Natural Killer inhibitory receptors display a conserved and fundamental function in the regulation of NK-mediated cytolysis. Their importance is substantiated by the fact that during speciation different molecular receptor structures have evolved to maintain inhibitory regulation of NK cells. The information gained during these last twenty years begins to be fruitfully used in the therapy of leukemias, but a lot has to be still done. In particular, we need to understand the role of activating KIR and their ligand(s), since their role in the course of different viral diseases is still intriguing.

Keywords: Killer inhibitory receptor, human leukocyte antigen, activating receptors, sialoadhesin

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Article Details

VOLUME: 15
ISSUE: 28
Year: 2009
Page: [3301 - 3310]
Pages: 10
DOI: 10.2174/138161209789105225
Price: $65

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