Non-Canonical Peptides Bound to MHC

Author(s): Stephanie L. Day, Paul A. Ramsland, Vasso Apostolopoulos

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 28 , 2009

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Abstract:

Central to the initiation of a T cell dependent immune response is the recognition of major histocompatibility complex (MHC) class I or class II molecules (in humans termed HLA and in mice termed H-2) bound to antigenic peptide. T cell receptors (TCR) have programmed specificity for particular peptide/MHC complexes, which ensures focused immune responses are generated against the antigen source. To design effective peptide based vaccines a comprehensive understanding of the specific interactions between MHC molecules and peptide, and of TCR recognition of MHC/peptide is valuable. We place particular emphasis on non-canonical bound peptides and their use in immunotherapy studies.

Keywords: Non-canonical peptides, MHC class I, vaccine

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Article Details

VOLUME: 15
ISSUE: 28
Year: 2009
Page: [3274 - 3282]
Pages: 9
DOI: 10.2174/138161209789105090
Price: $65

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