Prediction of MHC-Peptide Binding: A Systematic and Comprehensive Overview

Author(s): Esther M. Lafuente, Pedro A. Reche

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 28 , 2009

Become EABM
Become Reviewer

Abstract:

T cell immune responses are driven by the recognition of peptide antigens (T cell epitopes) that are bound to major histocompatibility complex (MHC) molecules. T cell epitope immunogenicity is thus contingent on several events, including appropriate and effective processing of the peptide from its protein source, stable peptide binding to the MHC molecule, and recognition of the MHC-bound peptide by the T cell receptor. Of these three hallmarks, MHC-peptide binding is the most selective event that determines T cell epitopes. Therefore, prediction of MHC-peptide binding constitutes the principal basis for anticipating potential T cell epitopes. The tremendous relevance of epitope identification in vaccine design and in the monitoring of T cell responses has spurred the development of many computational methods for predicting MHC-peptide binding that improve the efficiency and economics of T cell epitope identification. In this report, we will systematically examine the available methods for predicting MHC-peptide binding and discuss their most relevant advantages and drawbacks.

Keywords: Peptide, T cells, epitopes, MHC, HLA, prediction

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 15
ISSUE: 28
Year: 2009
Page: [3209 - 3220]
Pages: 12
DOI: 10.2174/138161209789105162

Article Metrics

PDF: 52