Abstract
The use of nanoscale structures and features is becoming increasingly popular in tissue engineering, and for good reason. Devices that have features in the nano-length scale offer many benefits that their counterparts do not. These features can alter cellular behavior including cell attachment, degree of cell spreading, and cellular alignment. These properties affect the arrangement of extracellular matrix material produced by attached cells. Nano to micro-scale porosity is important for cellular infiltration into long term or degradable implants. Features of this length scale model the structures that cells typically see in vivo, therefore they tend to respond positively when placed on nano length structures. The inclusion of nanoscale features or use of nanoscale structures improves the cellular response to the implant and increases tissue bonding thereby reducing the chances of implant failure. Nanoscale structures can also enhance device strength; by combining nanoscale, high moduli particles with more flexible, weaker materials one can create high strength composites for bone tissue engineering. There are a host of ways to create nanostructures or create nanoscale features on an implant including electrospinning, nanoetching, and the creation of nanospheres. They all produce roughness, pores, or alignment in the nanoscale which is essential for tissue engineering success. These techniques encompass a wide range of materials and methods. Several of these techniques and their applications will be discussed in this paper.
Current Bioactive Compounds
Title: Nanostructures for Treating Musculoskeletal Conditions
Volume: 5 Issue: 3
Author(s): Joseph W. Freeman and M. Nichole Rylander
Affiliation:
Abstract: The use of nanoscale structures and features is becoming increasingly popular in tissue engineering, and for good reason. Devices that have features in the nano-length scale offer many benefits that their counterparts do not. These features can alter cellular behavior including cell attachment, degree of cell spreading, and cellular alignment. These properties affect the arrangement of extracellular matrix material produced by attached cells. Nano to micro-scale porosity is important for cellular infiltration into long term or degradable implants. Features of this length scale model the structures that cells typically see in vivo, therefore they tend to respond positively when placed on nano length structures. The inclusion of nanoscale features or use of nanoscale structures improves the cellular response to the implant and increases tissue bonding thereby reducing the chances of implant failure. Nanoscale structures can also enhance device strength; by combining nanoscale, high moduli particles with more flexible, weaker materials one can create high strength composites for bone tissue engineering. There are a host of ways to create nanostructures or create nanoscale features on an implant including electrospinning, nanoetching, and the creation of nanospheres. They all produce roughness, pores, or alignment in the nanoscale which is essential for tissue engineering success. These techniques encompass a wide range of materials and methods. Several of these techniques and their applications will be discussed in this paper.
Export Options
About this article
Cite this article as:
Freeman W. Joseph and Rylander Nichole M., Nanostructures for Treating Musculoskeletal Conditions, Current Bioactive Compounds 2009; 5 (3) . https://dx.doi.org/10.2174/157340709789054731
DOI https://dx.doi.org/10.2174/157340709789054731 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Contrast Agents in X-Ray Computed Tomography and Its Applications in Oncology
Anti-Cancer Agents in Medicinal Chemistry Anticancer Activity of New Haloalkyl Camptothecin Esters against Human Cancer Cell Lines and Human Tumor Xenografts Grown in Nude Mice
Anti-Cancer Agents in Medicinal Chemistry The Neuroprotective Effect of Ginkgo biloba Leaf Extract and its Possible Mechanism
Central Nervous System Agents in Medicinal Chemistry Neuronal Nicotinic Acetylcholine Receptors - Targets for the Development of Drugs to Treat Cognitive Impairment Associated with Schizophrenia and Alzheimers Disease
Current Topics in Medicinal Chemistry Diabetes Mellitus: Novel Insights, Analysis and Interpretation of Pathophysiology and Complications Management with Imidazole-Containing Peptidomimetic Antioxidants
Recent Patents on Drug Delivery & Formulation NTproBNP: An Important Biomarker in Cardiac Diseases
Current Topics in Medicinal Chemistry Glucose Transporters Regulation on Ischemic Brain: Possible Role as Therapeutic Target
Central Nervous System Agents in Medicinal Chemistry Rational Drug Design for Identifying Novel Multi-target Inhibitors for Hepatocellular Carcinoma
Anti-Cancer Agents in Medicinal Chemistry Properties of the Mesenchymal Endometriotic Stem Cell in the Context of the Immune System and Analysis of its Role in Endometriosis
Recent Patents on Regenerative Medicine Gankyrin Oncoprotein: Structure, Function, and Involvement in Cancer
Current Chemical Biology Countermeasures to the Bioterrorist Threat of Smallpox
Current Molecular Medicine The Role of COX-2 in Acute Pain and the Use of Selective COX-2 Inhibitors for Acute Pain Relief
Current Pharmaceutical Design Analogue of Melanotan II (MTII): A Novel Melanotropin with Superpotent Action on Frog Skin
Protein & Peptide Letters Nanoparticle Therapy for Allergic and Inflammatory Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Ecto-Nucleotidase Inhibitors: Recent Developments in Drug Discovery
Mini-Reviews in Medicinal Chemistry Biological Basis of Novel Therapies for Myelodysplastic Syndrome
Current Cancer Therapy Reviews Subpopulations of Bone Marrow Mesenchymal Stem Cells Exhibit Differential Effects in Delaying Retinal Degeneration
Current Molecular Medicine Angiotensin-Converting Enzyme - New Insights into Structure, Biological Significance and Prospects for Domain-Selective Inhibitors
Current Enzyme Inhibition Plant Natural Products in Anticancer Drug Discovery
Current Organic Chemistry Colony-Stimulating Factor-1 Receptor Inhibitors for the Treatment of Cancer and Inflammatory Disease
Current Topics in Medicinal Chemistry