Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins

Author(s): Jin Zhang, Xinbin Chen

Journal Name: Current Molecular Medicine

Volume 8 , Issue 8 , 2008

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p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.

Keywords: p53, posttranscriptional regulation, RNA-binding proteins, translational regulation, mRNA decay

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Article Details

Year: 2008
Page: [845 - 849]
Pages: 5
DOI: 10.2174/156652408786733748
Price: $65

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