Title: Posttranscriptional Regulation of p53 and its Targets by RNABinding Proteins
VOLUME: 8 ISSUE: 8
Author(s):Jin Zhang and Xinbin Chen
Affiliation:Tupper 2128, VM: Surgical and Radiological Sciences, University of California at Davis, Davis, CA 95616, USA.
Keywords:p53, posttranscriptional regulation, RNA-binding proteins, translational regulation, mRNA decay
Abstract: p53 tumor suppressor plays a pivotal role in maintaining genomic integrity and preventing cancer development. The importance of p53 in tumor suppression is illustrated by the observation that about 50% human tumor cells have a dysfunctional p53 pathway. Although it has been well accepted that the activity of p53 is mainly controlled through post-translational modifications, recent studies have revealed that posttranscriptional regulations of p53 by various RNA-binding proteins also play a crucial role in modulating p53 activity and its downstream targets.
