Identifying the Metabolic Syndrome in Obese Children and Adolescents: Do Age and Definition Matter?

Author(s): Mariska van Vliet, Ines A. von Rosenstiel, Roger K. Schindhelm, Desiderius P.M. Brandjes, Jos H. Beijnen, Michaela Diamant

Journal Name: Current Clinical Pharmacology

Volume 4 , Issue 3 , 2009

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Abstract:

Objectives: To assess the prevalence of the metabolic syndrome (MetS) in overweight/obese children and adolescents of an out-patient clinic, and to compare two definitions of MetS in adolescents. Methods: In total, 528 overweight/obese children (3-16 years), of multi-ethnic origin, underwent an oral glucose tolerance test, blood collections and anthropometric measurements. In children < 10 years, MetS was assessed according to childspecific cut-off values (MetS-child). In adolescents, MetS-child and MetS-adolescent (the recommendation of the International Diabetes Federation for adolescents) were compared. Results: The prevalence of MetS-child within the cohort (median age 11.3, range 3.1-16.4 years) was 18.6% (children < 10 years vs. adolescents: 14.1% vs. 20.7%, P=0.073). Insulin resistance was present in 47.7% (children < 10 years vs. adolescents: 21.8% vs. 60.1%, P < 0.001). MetS-child was highly prevalent, and not statistically significant between age groups. In adolescents, the prevalence of MetS-adolescent was higher than MetS-child (33.2% vs. 20.7%, P < 0.001). The agreement between the MetS definitions was moderate (κ=0.51), with the agreement for the MetS-criteria for abnormal lipid levels being substantial to very good (κ=0.71 to 0.80). Conclusions: MetS-child was highly prevalent in overweight/obese children and adolescents. A higher prevalence of MetS according to adolescent- as compared to child-specific criteria was found.

Keywords: Insulin resistance, obesity, overweight, metabolic syndrome X, paediatrics, risk factors

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2009
Page: [233 - 238]
Pages: 6
DOI: 10.2174/157488409789375276
Price: $65

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