Molecular Determinants of Fluoroquinolone Antibacterial Agents Pharmacokinetics

Author(s): Dominique Leveque, Francois Jehl

Journal Name: Current Clinical Pharmacology

Volume 4 , Issue 3 , 2009

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Abstract:

This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.

Keywords: Fluoroquinolone, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, pharmacokinetics, enzymes, drug transporters

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2009
Page: [191 - 197]
Pages: 7
DOI: 10.2174/157488409789375348
Price: $65

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