Abstract
Hypertension is one of the major risk factors for cardiovascular disease. Angiotensin receptor blockers (ARBs) are a class of antihypertensive drugs with established efficacy and favorable safety profile. Telmisartan, a member of the ARB family, holds some additional traits which differentiate it from the rest ARBs. A pivotal role in these characteristics plays its ability to partially activate the peroxisome proliferator activated receptor-γ, which in turn controls a number of metabolism-related genes. Indeed, telmisartan has shown a number of pleiotropic effects in experimental and clinical studies. These include the amelioration of insulin resistance, improvement of lipid profile and favorable fat redistribution. Moreover, telmisartan has been associated with beneficial effects on vascular function, cardiac remodeling and renal function. However, do all these pleiotropic effects translate into clinical benefit? Recent studies have tried to answer this question with promising but not definitive results.
Keywords: Angiotensin receptor blockers, cardiovascular disease, diabetes development, heart failure, pleiotropic effects, renal disease, stroke, telmisartan
Current Pharmaceutical Design
Title: Are the Pleiotropic Effects of Telmisartan Clinically Relevant?
Volume: 15 Issue: 24
Author(s): C. V. Rizos, M. S. Elisaf and E. N. Liberopoulos
Affiliation:
Keywords: Angiotensin receptor blockers, cardiovascular disease, diabetes development, heart failure, pleiotropic effects, renal disease, stroke, telmisartan
Abstract: Hypertension is one of the major risk factors for cardiovascular disease. Angiotensin receptor blockers (ARBs) are a class of antihypertensive drugs with established efficacy and favorable safety profile. Telmisartan, a member of the ARB family, holds some additional traits which differentiate it from the rest ARBs. A pivotal role in these characteristics plays its ability to partially activate the peroxisome proliferator activated receptor-γ, which in turn controls a number of metabolism-related genes. Indeed, telmisartan has shown a number of pleiotropic effects in experimental and clinical studies. These include the amelioration of insulin resistance, improvement of lipid profile and favorable fat redistribution. Moreover, telmisartan has been associated with beneficial effects on vascular function, cardiac remodeling and renal function. However, do all these pleiotropic effects translate into clinical benefit? Recent studies have tried to answer this question with promising but not definitive results.
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Cite this article as:
Rizos V. C., Elisaf S. M. and Liberopoulos N. E., Are the Pleiotropic Effects of Telmisartan Clinically Relevant?, Current Pharmaceutical Design 2009; 15 (24) . https://dx.doi.org/10.2174/138161209788923859
DOI https://dx.doi.org/10.2174/138161209788923859 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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