Abstract
Mesoporous silica particles (MSP) are a new development in nanotechnology. Covalent modification of the surface of the silica is possible both on the internal pore and on the external particle surface. It allows the design of functional nanostructured materials with properties of organic, biological and inorganic components. Research and development are ongoing on the MSP, which have applications in catalysis, drug delivery and imaging. The most recent and interesting advancements in size, morphology control and surface functionalization of MSP have enhanced the biocompatibility of these materials with high surface areas and pore volumes. In the last 5 years several reports have demonstrated that MSP can be efficiently internalized using in vitro and animal models. The functionalization of MSP with organic moieties or other nanostructures brings controlled release and molecular recognition capabilities to these mesoporous materials for drug/gene delivery and sensing applications, respectively. Herein, we review recent research progress on the design of functional MSP materials with various mechanisms of targeting and controlled release.
Keywords: Hybrid mesoporous materials, multifunctional mesoporous silica, drug delivery systems, drug targeting device
Current Medicinal Chemistry
Title: Recent Development, Applications, and Perspectives of Mesoporous Silica Particles in Medicine and Biotechnology
Volume: 16 Issue: 23
Author(s): Luigi Pasqua, Sante Cundari, Cecilia Ceresa and Guido Cavaletti
Affiliation:
Keywords: Hybrid mesoporous materials, multifunctional mesoporous silica, drug delivery systems, drug targeting device
Abstract: Mesoporous silica particles (MSP) are a new development in nanotechnology. Covalent modification of the surface of the silica is possible both on the internal pore and on the external particle surface. It allows the design of functional nanostructured materials with properties of organic, biological and inorganic components. Research and development are ongoing on the MSP, which have applications in catalysis, drug delivery and imaging. The most recent and interesting advancements in size, morphology control and surface functionalization of MSP have enhanced the biocompatibility of these materials with high surface areas and pore volumes. In the last 5 years several reports have demonstrated that MSP can be efficiently internalized using in vitro and animal models. The functionalization of MSP with organic moieties or other nanostructures brings controlled release and molecular recognition capabilities to these mesoporous materials for drug/gene delivery and sensing applications, respectively. Herein, we review recent research progress on the design of functional MSP materials with various mechanisms of targeting and controlled release.
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Cite this article as:
Pasqua Luigi, Cundari Sante, Ceresa Cecilia and Cavaletti Guido, Recent Development, Applications, and Perspectives of Mesoporous Silica Particles in Medicine and Biotechnology, Current Medicinal Chemistry 2009; 16 (23) . https://dx.doi.org/10.2174/092986709788803079
DOI https://dx.doi.org/10.2174/092986709788803079 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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