N-Alkylated Guanine Derivatives

Author(s): G. Ferenc, P. Padar, J. Szolomajer, L. Kovacs.

Journal Name: Current Organic Chemistry

Volume 13 , Issue 11 , 2009

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The synthesis, chemical, physical, biological, spectroscopic and miscellaneous analytical properties of Nalkylguanine derivatives substituted at 1-, 1,N²-, N -, 3-, 3,N -, 7-, 7,9- and 9-positions have been surveyed, mainly from the 2003-2009 period. Beyond the synthetic methods, particular emphasis has been given to products of mutagenesis and carcinogenesis, the role of modified fluorescent guanosines (wyosine, wyebutosine), mRNA cap structures and drugs stemming from N-alkylguanines. The review is based on 154 references and contains 64 schemes with 355 numbered structures.

Keywords: Nalkylguanine, Derivatives, synthesis, mutagenesis, carcinogenesis

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Article Details

Year: 2009
Page: [1085 - 1135]
Pages: 51
DOI: 10.2174/138527209788680718
Price: $58

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