2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery

Author(s): A. A. Weekes, A. D. Westwell

Journal Name: Current Medicinal Chemistry

Volume 16 , Issue 19 , 2009

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Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimers disease and as antitumour agents.

Keywords: 2-Arylbenzothiazoles, synthesis, Alzheimer's disease diagnosis, positron emission tomography, antitumour agents

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Article Details

Year: 2009
Page: [2430 - 2440]
Pages: 11
DOI: 10.2174/092986709788682137
Price: $65

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