Mechanisms of Protein Aggregation

Author(s): John S. Philo, Tsutomu Arakawa

Journal Name: Current Pharmaceutical Biotechnology

Volume 10 , Issue 4 , 2009

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Abstract:

Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.

Keywords: Aggregation, self-association, mechanism, nucleation

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2009
Page: [348 - 351]
Pages: 4
DOI: 10.2174/138920109788488932
Price: $65

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