Abstract
Acquisition of resistance to the cytotoxic effects of anticancer agents is one of the most significant impediments to effective cancer therapy. Although various cancer-cell intrinsic mechanisms of drug resistance have been identified, chemotherapy resistance remains one of the major causes of cancer patient death. Emerging evidence suggests that the inflammatory tumor-microenvironment plays an important additional role in modulating drug responsiveness and drug resistance; however, underlying mechanisms are still largely unknown. In this review, we discuss data supporting the idea that crosstalk between components of the immune system and cancer cells can influence chemoresistance, and we will speculate on possible underlying pathways and clinical implications. A deeper understanding of the cancer cell-intrinsic and – extrinsic mechanisms of drug resistance will accelerate the development of novel combinatorial anticancer therapies in which drug resistance is prevented or reversed.
Keywords: Cancer, inflammation, chemoresistance, microenvironment, chemotherapy
Current Pharmaceutical Design
Title: Towards Understanding the Role of Cancer-Associated Inflammation in Chemoresistance
Volume: 15 Issue: 16
Author(s): Karin E. de Visser and Jos Jonkers
Affiliation:
Keywords: Cancer, inflammation, chemoresistance, microenvironment, chemotherapy
Abstract: Acquisition of resistance to the cytotoxic effects of anticancer agents is one of the most significant impediments to effective cancer therapy. Although various cancer-cell intrinsic mechanisms of drug resistance have been identified, chemotherapy resistance remains one of the major causes of cancer patient death. Emerging evidence suggests that the inflammatory tumor-microenvironment plays an important additional role in modulating drug responsiveness and drug resistance; however, underlying mechanisms are still largely unknown. In this review, we discuss data supporting the idea that crosstalk between components of the immune system and cancer cells can influence chemoresistance, and we will speculate on possible underlying pathways and clinical implications. A deeper understanding of the cancer cell-intrinsic and – extrinsic mechanisms of drug resistance will accelerate the development of novel combinatorial anticancer therapies in which drug resistance is prevented or reversed.
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Cite this article as:
de Visser E. Karin and Jonkers Jos, Towards Understanding the Role of Cancer-Associated Inflammation in Chemoresistance, Current Pharmaceutical Design 2009; 15 (16) . https://dx.doi.org/10.2174/138161209788453239
DOI https://dx.doi.org/10.2174/138161209788453239 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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