Lactoferrin as a Natural Immune Modulator

Author(s): Jeffrey K. Actor, Shen-An Hwang, Marian L. Kruzel

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 17 , 2009

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Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the influence of presenting cells for the development of T-helper cell polarization. The aim of this review is to provide an overview of research regarding the role of lactoferrin in maintaining immune homeostasis, in particular as a mediator of immune responses to infectious assault, trauma and injury. These findings are critically relevant in the development of both prophylactic and therapeutic interventions in humans. Understanding these particular effects of lactoferrin will provide a logical framework for determining its role in health and disease.

Keywords: Lactoferrin, innate immunity, adaptive immunity, immunomodulation, inflammation, oxidative stress, adjuvant

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Article Details

Year: 2009
Page: [1956 - 1973]
Pages: 18
DOI: 10.2174/138161209788453202
Price: $65

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PDF: 18