Abstract
The success of anti-cancer therapy largely relies on the development of high-efficient, low-toxic, long-circulated, and cancertargeted drug delivery systems. Currently used pharmaceutical nanocarriers, such as polymeric nanoparticles (NPs), liposomes, micelles, nanoemulsions, and many others demonstrate a variety of useful properties, including long circulation in the blood allowing for their accumulation in cancer sites with fenestrated vasculature and poor lymphatic drainage. Surface-modification of nanocarriers is attractive for their enhanced functions on imaging, targeting and delivery. Due to various targeting ligands attached to the surface of the nanocarriers, they could prolong circulation time, increase drug bioavailability, reduce undesirable side effects, and minimize non-specific uptake thus allow for specific cancer-targeting to certain target cells within the cancer sites or even intracellular localization to target organelles. This review highlights the different types of the surface modification of various drug or gene loaded nanocarriers for cancer therapy, focusing on their modification methods, advantages, applications and the probable associated drawbacks.
Keywords: Nanocarriers, surface-modification, cancer therapy, drug and gene delivery
Current Nanoscience
Title: Surface Modification of Nanocarriers for Cancer Therapy
Volume: 5 Issue: 2
Author(s): Wang-yang Yu and Na Zhang
Affiliation:
Keywords: Nanocarriers, surface-modification, cancer therapy, drug and gene delivery
Abstract: The success of anti-cancer therapy largely relies on the development of high-efficient, low-toxic, long-circulated, and cancertargeted drug delivery systems. Currently used pharmaceutical nanocarriers, such as polymeric nanoparticles (NPs), liposomes, micelles, nanoemulsions, and many others demonstrate a variety of useful properties, including long circulation in the blood allowing for their accumulation in cancer sites with fenestrated vasculature and poor lymphatic drainage. Surface-modification of nanocarriers is attractive for their enhanced functions on imaging, targeting and delivery. Due to various targeting ligands attached to the surface of the nanocarriers, they could prolong circulation time, increase drug bioavailability, reduce undesirable side effects, and minimize non-specific uptake thus allow for specific cancer-targeting to certain target cells within the cancer sites or even intracellular localization to target organelles. This review highlights the different types of the surface modification of various drug or gene loaded nanocarriers for cancer therapy, focusing on their modification methods, advantages, applications and the probable associated drawbacks.
Export Options
About this article
Cite this article as:
Yu Wang-yang and Zhang Na, Surface Modification of Nanocarriers for Cancer Therapy, Current Nanoscience 2009; 5 (2) . https://dx.doi.org/10.2174/157341309788185370
DOI https://dx.doi.org/10.2174/157341309788185370 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Recent Advances In Developing Novel Anti-Cancer Drugs Targeting Tumor Hypoxic and Acidic Microenvironments
Recent Patents on Anti-Cancer Drug Discovery MicroRNA-21: From Cancer to Cardiovascular Disease
Current Drug Targets Strategies to Overcome Multi-Drug Resistance in Cancer Cells: the Contribution of siRNA and Nanotechnologies
Current Organic Chemistry Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment
Current Cancer Therapy Reviews Novel Beta-Lactam Antibiotics Derivatives: Their New Applications as Gene Reporters, Antitumor Prodrugs and Enzyme Inhibitors
Mini-Reviews in Medicinal Chemistry Synergistic Interaction of Telomerase-Specific Oncolytic Virotherapy and Chemotherapeutic Agents for Human Cancer
Current Pharmaceutical Biotechnology Anti-Cancer Effects of a New Docosahexaenoic Acid Monoacylglyceride in Lung Adenocarcinoma
Recent Patents on Anti-Cancer Drug Discovery A Novel Highly Selective Cannabinoid CB2 Agonist Reduces in vitro Growth and TGF-beta Release of Human Glial Cell Tumors
Central Nervous System Agents in Medicinal Chemistry Exosomal MicroRNAs in Tumoral U87 MG Versus Normal Astrocyte Cells
MicroRNA Advances and Future Challenges in Adenoviral Vector Pharmacology and Targeting
Current Gene Therapy Intracellular Fate of Peptide-Mediated Delivered Cargoes
Current Pharmaceutical Design The Role and Therapeutic Potential of Ser/Thr Phosphatase PP2A in Apoptotic Signalling Networks in Human Cancer Cells
Current Molecular Medicine Targeting EGFR in Pancreatic Cancer Treatment
Current Drug Targets Nanostructures for Bypassing Blood Brain Barrier
Current Bioactive Compounds A 1536-Well Fluorescence Polarization Assay to Screen for Modulators of the MUSASHI Family of RNA-Binding Proteins
Combinatorial Chemistry & High Throughput Screening Fibroblast Growth Factor-2 Antagonist and Antiangiogenic Activity of Long-Pentraxin 3-Derived Synthetic Peptides
Current Pharmaceutical Design Antiproliferative Efficacy of Angiotensin II Receptor Blockers in Prostate Cancer
Current Cancer Drug Targets Exercise-Induced Overexpression of Angiogenic Factors and Reduction of Ischemia / Reperfusion Injury in Stroke
Current Neurovascular Research Marine Natural Products with High Anticancer Activities
Current Medicinal Chemistry Anaplastic Lymphoma Kinase as a Therapeutic Target in Anaplastic Large Cell Lymphoma, Non-Small Cell Lung Cancer and Neuroblastoma
Anti-Cancer Agents in Medicinal Chemistry