Abstract
Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodeling whereas MMP-9 is closely related to coronary diseases. We postulate that ACE inhibitors prevent coronary diseases via direct MMP-9 inhibition and could interact with the MMP-9 active sites using specific modes similar to those used for the ACE active sites. Research of the molecular interaction between MMP-9 active sites and ACE inhibitors appears to be an important key in the development of effective MMP-9 inhibitors for cardiovascular protection.
Keywords: Matrix metalloproteinase-9, angiotensin converting enzyme inhibitor, angiotensin II receptor blocker, myocardial infarction, cardiovascular protection, coronary diseases, molecular interaction, inhibitory specificity
Current Medicinal Chemistry
Title: Pharmacological Implications of MMP-9 Inhibition by ACE Inhibitors
Volume: 16 Issue: 11
Author(s): Daisuke Yamamoto and Shinji Takai
Affiliation:
Keywords: Matrix metalloproteinase-9, angiotensin converting enzyme inhibitor, angiotensin II receptor blocker, myocardial infarction, cardiovascular protection, coronary diseases, molecular interaction, inhibitory specificity
Abstract: Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodeling whereas MMP-9 is closely related to coronary diseases. We postulate that ACE inhibitors prevent coronary diseases via direct MMP-9 inhibition and could interact with the MMP-9 active sites using specific modes similar to those used for the ACE active sites. Research of the molecular interaction between MMP-9 active sites and ACE inhibitors appears to be an important key in the development of effective MMP-9 inhibitors for cardiovascular protection.
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Cite this article as:
Yamamoto Daisuke and Takai Shinji, Pharmacological Implications of MMP-9 Inhibition by ACE Inhibitors, Current Medicinal Chemistry 2009; 16 (11) . https://dx.doi.org/10.2174/092986709787846514
DOI https://dx.doi.org/10.2174/092986709787846514 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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