Antimitotic Chalcones and Related Compounds as Inhibitors of Tubulin Assembly

Author(s): Sylvie Ducki

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 9 , Issue 3 , 2009

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The development of chalcones as antimitotic agents has led to the design of other analogues able to interact with tubulin and inhibit its assembly into microtubules. This activity has also been associated with their anti-vascular activity. This review focuses on the development of chalcones and related analogues as antimitotic agents.

Keywords: Chalcone, tubulin, microtubule, antimitotic, cytotoxic

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Article Details

Year: 2009
Page: [336 - 347]
Pages: 12
DOI: 10.2174/1871520610909030336
Price: $65

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PDF: 17