Peptides for Tumour Therapy and Diagnosis: Current Status and Future Directions

Author(s): Laura Zaccaro, Annarita del Gatto, Carlo Pedone, Michele Saviano

Journal Name: Current Medicinal Chemistry

Volume 16 , Issue 7 , 2009

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The use of peptides as targeting tools has been validated in different applications. In particular radiolabelled peptides with adequate stability, receptor-binding properties and biokinetic behaviour have been investigated as an important class of radiopharmaceuticals for cancer pathology imaging and therapy. This review focuses on recent progress in design and synthetic modifications of small biologically active peptides used in diagnosis and therapy. In particular, we report the current development and optimization of suitable peptides for targeting three relevant biological receptors (CCK, somatostatin, and integrin receptors) involved in specific tumour diseases.

Keywords: CCK, somatostatin, integrin, structure-activity relationships, tumour diseases

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Article Details

Year: 2009
Page: [780 - 795]
Pages: 16
DOI: 10.2174/092986709787549307
Price: $65

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