Abstract
In the last fifteen years different extracellular matrix proteins and cleavage products have been identified. These molecules possess the ability to regulate vascular development, repair and function. However, the concept is still inconsistent and only partially understood. In this review, we will focus on angiogenesis regulation by extracellular matrix processing. Therefore, possible regulatory mechanisms in vascular biology controlled by different cleavage products of basement membrane proteins (e.g. endostatin and tumstatin, endorepellin), their activation by proteases and inhibitors, such as matrix metalloproteases (MMPs), cathepsins, tissue inhibitors of MMPs and cystatin, will be reviewed. Up to now there is only limited knowledge about the situations, under which different ECM cleavage products will be released and produced by proteases. Beside vascular growth and the formation of new blood vessels, it is also important to pay attention to the implication of the mentioned proteins in the vascular repair process. Physical exercise and its angio-regulatory potentials have become in the focus in recent years. We will therefore discuss physical exercise and its effects on the mentioned molecules regarding angiogenic inductions. Until today it remains to be clearly stated, which impact might be achieved by matrix cleavage products with respect to the regulation of vascular progenitor cells and their possible therapeutical role in support of vascular repair mechanisms. Furthermore, the current knowledge of the functional role of ECM in the vascular system is highlighted.
Current Pharmaceutical Design
Title: Angiogenic and Vascular Modulation by Extracellular Matrix Cleavage Products
Volume: 15 Issue: 4
Author(s): Frank Suhr, Klara Brixius and Wilhelm Bloch
Affiliation:
Abstract: In the last fifteen years different extracellular matrix proteins and cleavage products have been identified. These molecules possess the ability to regulate vascular development, repair and function. However, the concept is still inconsistent and only partially understood. In this review, we will focus on angiogenesis regulation by extracellular matrix processing. Therefore, possible regulatory mechanisms in vascular biology controlled by different cleavage products of basement membrane proteins (e.g. endostatin and tumstatin, endorepellin), their activation by proteases and inhibitors, such as matrix metalloproteases (MMPs), cathepsins, tissue inhibitors of MMPs and cystatin, will be reviewed. Up to now there is only limited knowledge about the situations, under which different ECM cleavage products will be released and produced by proteases. Beside vascular growth and the formation of new blood vessels, it is also important to pay attention to the implication of the mentioned proteins in the vascular repair process. Physical exercise and its angio-regulatory potentials have become in the focus in recent years. We will therefore discuss physical exercise and its effects on the mentioned molecules regarding angiogenic inductions. Until today it remains to be clearly stated, which impact might be achieved by matrix cleavage products with respect to the regulation of vascular progenitor cells and their possible therapeutical role in support of vascular repair mechanisms. Furthermore, the current knowledge of the functional role of ECM in the vascular system is highlighted.
Export Options
About this article
Cite this article as:
Suhr Frank, Brixius Klara and Bloch Wilhelm, Angiogenic and Vascular Modulation by Extracellular Matrix Cleavage Products, Current Pharmaceutical Design 2009; 15 (4) . https://dx.doi.org/10.2174/138161209787315756
DOI https://dx.doi.org/10.2174/138161209787315756 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cognitive Decline as a Consequence of Essential Hypertension
Current Pharmaceutical Design Diabetes Mellitus and Renal Function: Current Medical Research and Opinion
Current Diabetes Reviews Effectiveness of Psychoeducational Interventions for Improving Symptoms, Health-Related Quality of Life, and Psychological well Being in Patients with Stable Angina
Current Cardiology Reviews Homocysteine and Heart Failure: An Overview
Recent Patents on Cardiovascular Drug Discovery Atherosclerosis is an Inflammatory Disorder After All
Current Topics in Medicinal Chemistry Clinical Studies with Paclitaxel - Eluting Stent Systems
Current Pharmaceutical Design The Developing Role of Neuregulin1 In Cardiac Regenerative Stem Cell Therapy
Current Pharmaceutical Design Targeting Cardiomyocyte Ca<sup>2+</sup> Homeostasis in Heart Failure
Current Pharmaceutical Design Hesperidin Potentiates Ghrelin Signaling
Recent Patents on Food, Nutrition & Agriculture The Effect of Dual-Task Testing on Balance and Gait Performance in Adults with Type 1 or Type 2 Diabetes Mellitus: A Systematic Review
Current Diabetes Reviews Roles of Adrenomedullin in Hypertension and Hypertensive Organ Damage
Current Hypertension Reviews A Review of Recent Patents on the Protozoan Parasite HSP90 as a Drug Target
Recent Patents on Biotechnology Anti-Cancer Drugs Targeting Fatty Acid Synthase (FAS)
Recent Patents on Anti-Cancer Drug Discovery Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions
Current Medicinal Chemistry Mitochondrial Proteases as Emerging Pharmacological Targets
Current Pharmaceutical Design Modern Therapeutic Strategies for Autoimmune Diseases
Current Pharmaceutical Design The Innate Immune System and Fever under Redox Control: A Narrative Review
Current Medicinal Chemistry Therapeutically Targeting MicroRNAs in Liver Cancer
Current Pharmaceutical Design The Gut Microbiota in Cardiovascular Diseases: From Biomarkers and Potential Targets to Personalized Interventions
Current Pharmacogenomics and Personalized Medicine Endothelin Signalling in the Cardiac Myocyte and its Pathophysiological Relevance
Current Vascular Pharmacology