The Importance of Steroidomics in the Study of Neurodegenerative Disease and Ageing

Author(s): William J. Griffiths, Yuqin Wang

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 12 , Issue 2 , 2009

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In this mini review, the importance of experimental steroidomics in the study of neurodegenerative disease and aging is discussed. Attention is focused on just one class of lipid which is based on the cyclopentanoperhydrophenanthrene ring system. Experimental methods for steroidomic analysis are reviewed, and the potential to use these methods to diagnose disease and to gain a better understanding of neurodegenerative disorders is examined.

Keywords: Mass spectrometry, tandem mass spectrometry, sterols, steroids, Alzheimer's disease, brain, CNS

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Article Details

Year: 2009
Page: [212 - 228]
Pages: 17
DOI: 10.2174/138620709787315472
Price: $65

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