Pleiotropic Effects of Fenofibrate

Author(s): V. Tsimihodimos, E. Liberopoulos, M. Elisaf

Journal Name: Current Pharmaceutical Design

Volume 15 , Issue 5 , 2009

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Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms. This review considers the clinical pharmacology of fenofibrate and the current evidence on the pleiotropic effects of this fibric acid derivative.

Keywords: Fenofibrate, pleiotropic effects, inflammation, endothelial function, oxidative stress, lipoprotein-associated enzymes, cardiac remodeling, angiogenesis

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Article Details

Year: 2009
Published on: 01 March, 2012
Page: [517 - 528]
Pages: 12
DOI: 10.2174/138161209787315675
Price: $65

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