Targeting the Tumor Stroma in Cancer Therapy

Author(s): Kevin Anton, John Glod

Journal Name: Current Pharmaceutical Biotechnology

Volume 10 , Issue 2 , 2009

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Increasing evidence shows that the interaction between neoplastic cells and the surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of diverse cellular populations including macrophages, lymphocytes, vascular cells, and carcinoma-associated fibroblasts. The complex interactions between the stroma and neoplastic cells are largely unexplored. Initial therapies aimed at disrupting angiogenesis within the tumor microenvironment have met with success in a number of tumor types. An improved understanding of stromal signaling pathways is likely to identify additional novel therapeutic targets.

Keywords: Tumor Stroma, Cancer Therapy, neoplastic cells, lymphocytes, vascular cells, angiogenesis

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Article Details

Year: 2009
Published on: 01 March, 2012
Page: [185 - 191]
Pages: 7
DOI: 10.2174/138920109787315088
Price: $65

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