Abstract
Aza-derivatives of phenols such as Schiff bases and hydrazones are an important and interesting group of chemical compounds. They exhibit a number of biological activities and play an important role in the regulation of many biochemical processes. Due to these properties, these compounds are potentialy useful for the design and production of novel anticancer, antimalaria, antivirus and antimicrobial drugs. The primary aim of the present review is to compare selected groups of phenol-derivatives containing azo-, heterocyclic, aromatic, alkyl and sugar moieties in view of their potential use and undesired effects, since some of them are widely used as dyes in the industry. Despite the vast number of azo derivatives of phenols which were synthesized and tested with respect to their biological activities, there is a continuous search for compounds of this group which might exhibit interesting, new biological effects.
Keywords: Schiff Bases, Azo Derivatives, Phenols, biological activities, antimalaria, antimicrobial drugs
Current Organic Chemistry
Title: Biological Properties of Schiff Bases and Azo Derivatives of Phenols
Volume: 13 Issue: 2
Author(s): Piotr Przybylski, Adam Huczynski, Krystian Pyta, Bogumil Brzezinski and Franz Bartl
Affiliation:
Keywords: Schiff Bases, Azo Derivatives, Phenols, biological activities, antimalaria, antimicrobial drugs
Abstract: Aza-derivatives of phenols such as Schiff bases and hydrazones are an important and interesting group of chemical compounds. They exhibit a number of biological activities and play an important role in the regulation of many biochemical processes. Due to these properties, these compounds are potentialy useful for the design and production of novel anticancer, antimalaria, antivirus and antimicrobial drugs. The primary aim of the present review is to compare selected groups of phenol-derivatives containing azo-, heterocyclic, aromatic, alkyl and sugar moieties in view of their potential use and undesired effects, since some of them are widely used as dyes in the industry. Despite the vast number of azo derivatives of phenols which were synthesized and tested with respect to their biological activities, there is a continuous search for compounds of this group which might exhibit interesting, new biological effects.
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Cite this article as:
Przybylski Piotr, Huczynski Adam, Pyta Krystian, Brzezinski Bogumil and Bartl Franz, Biological Properties of Schiff Bases and Azo Derivatives of Phenols, Current Organic Chemistry 2009; 13 (2) . https://dx.doi.org/10.2174/138527209787193774
DOI https://dx.doi.org/10.2174/138527209787193774 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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