Abstract
The purpose of the present study was to investigate the influence of method of preparation of large respirable particles of amikacin sulphate on traits and topography and in-vitro aerosol performance. Large respirable particles of amikacin sulfate (50%w/w) were produced by spray-drying and freeze-drying processes using hydrogenated soyaphosphatidylcholine, L-leucine and Poloxamer 188. Particles exhibited 0.04 – 0.08 g/cm3 tap densities, 7-20 μm geometric particle size, and 1 to 5 μm of mean aerodynamic diameter. Apart from the morphology and topographical features, spraydried and freeze- dried particles had marginal difference in their solid-state characteristics. Spray-dried particles were dimpled spherical shape with roundness value close to 1(1.066 ± 0.028), relatively smooth surface texture and produced greater aerosol dispersion with 20% higher fine particle fraction, 6.92% lower impaction loss and 13% less capsule and device retention than freeze dried particles. Traits and topographical features, such as particle size, polydispersity, elongation ratio, roundness, shape, and degree of surface roughness were found to be influenced significantly by spray-drying process and particles produced by spray-drying process showed better aerosol performance due to these differences.
Keywords: Large respirable particles, traits, topography, aerosol performance
Current Drug Delivery
Title: Aerosol Performance of Large Respirable Particles of Amikacin Sulfate Produced by Spray and Freeze Drying Techniques
Volume: 6 Issue: 1
Author(s): Bijay K. Padhi, Mahavir B. Chougule and Ambikanandan Misra
Affiliation:
Keywords: Large respirable particles, traits, topography, aerosol performance
Abstract: The purpose of the present study was to investigate the influence of method of preparation of large respirable particles of amikacin sulphate on traits and topography and in-vitro aerosol performance. Large respirable particles of amikacin sulfate (50%w/w) were produced by spray-drying and freeze-drying processes using hydrogenated soyaphosphatidylcholine, L-leucine and Poloxamer 188. Particles exhibited 0.04 – 0.08 g/cm3 tap densities, 7-20 μm geometric particle size, and 1 to 5 μm of mean aerodynamic diameter. Apart from the morphology and topographical features, spraydried and freeze- dried particles had marginal difference in their solid-state characteristics. Spray-dried particles were dimpled spherical shape with roundness value close to 1(1.066 ± 0.028), relatively smooth surface texture and produced greater aerosol dispersion with 20% higher fine particle fraction, 6.92% lower impaction loss and 13% less capsule and device retention than freeze dried particles. Traits and topographical features, such as particle size, polydispersity, elongation ratio, roundness, shape, and degree of surface roughness were found to be influenced significantly by spray-drying process and particles produced by spray-drying process showed better aerosol performance due to these differences.
Export Options
About this article
Cite this article as:
Padhi K. Bijay, Chougule B. Mahavir and Misra Ambikanandan, Aerosol Performance of Large Respirable Particles of Amikacin Sulfate Produced by Spray and Freeze Drying Techniques, Current Drug Delivery 2009; 6 (1) . https://dx.doi.org/10.2174/156720109787048267
DOI https://dx.doi.org/10.2174/156720109787048267 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
Call for Papers in Thematic Issues
Advances of natural products, bio-actives and novel drug delivery system against emerging viral infections
Due to the increasing prevalence of viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compounds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable ...read more
Electrospun Fibers as Drug Delivery Systems
In recent years, electrospun fibers have attracted considerable attention as potential platforms for drug delivery due to their distinctive properties and adaptability. These fibers feature a notable surface area-to-volume ratio and can be intentionally designed with high porosity, facilitating an increased capacity for drug loading and rendering them suitable for ...read more
Emerging Nanotherapeutics for Mitigation of Neurodegenerative Disorders
Conditions affecting the central nervous system (CNS) present a significant hurdle due to limited access of both treatments and diagnostic tools for the brain. The blood-brain barrier (BBB) acts as a barrier, restricting the passage of molecules from the bloodstream into the brain. The most formidable challenge facing scientists is ...read more
Nanotechnology Based Chemotherapy for the treatment of Head & Neck Cancer
The escalating recurrence rates observed in Head and Neck cancer, particularly within the chemo-therapeutically treated cohort (50-60%), can be attributed to the non-selective nature of current anticancer drug delivery modalities. In this context, nanotechnology-based drug delivery systems emerge as a promising avenue for achieving precise localization of therapeutic agents to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Evaluation of Topical Black Seed Oil in the Treatment of Allergic Rhinitis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Central Role of Leukotriene B4 in Epstein Barr Virus Activated Innate Immunity In Vitro
Current Immunology Reviews (Discontinued) Resisting the Sun with Vitamin D
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Mechanism of Mucus Production in Bronchial Asthma
Current Medicinal Chemistry Defense-related Proteins from Chelidonium majus L. as Important Components of its Latex
Current Protein & Peptide Science Insights on the Neuromodulatory Propensity of Selaginella (Sanjeevani) and its Potential Pharmacological Applications
CNS & Neurological Disorders - Drug Targets Subject Index to Volume 2
Current Pharmacogenomics New Treatments for COPD in the Elderly
Current Pharmaceutical Design Ethnomedicinal Uses, Phytochemistry and Pharmacology of Carica papaya Plant: A Compendious Review
Mini-Reviews in Organic Chemistry Tissue Distribution and Pharmacodynamics: A Complicated Relationship
Current Drug Metabolism Sulfated Oligosaccharides: New Targets for Drug Development?
Current Medicinal Chemistry Induction of Cytoprotective Genes Through Nrf2 / Antioxidant Response Element Pathway: A New Therapeutic Approach for the Treatment of Inflammatory Diseases
Current Pharmaceutical Design Th17 Cells in Airway Diseases
Current Molecular Medicine Proteome Analysis of Resting Human Neutrophils
Protein & Peptide Letters Psychopharmacologic Treatment of Children and Adolescents with Bipolar Disorder: A Review
Adolescent Psychiatry Nanoparticles Adjuvants in Allergology: New Challenges and Pitfalls
Current Pharmaceutical Design Redox-Active Selenium in Health and Disease: A Conceptual Review
Mini-Reviews in Medicinal Chemistry Binding Interactions of Forskolin with Human Serum Albumin: Insights from In silico and Spectroscopic Studies
Current Chemical Biology NF-κB in Anti-Inflammatory Activity of Probiotics: An Update
Current Immunology Reviews (Discontinued) Advances in Development of Phosphatidylinositol 3-Kinase Inhibitors
Current Medicinal Chemistry