Abstract
Circulating endothelial cell (CEC) and progenitor (CEP) number and viability are modulated in various pathological conditions including cancer. There is increasing evidence showing that CEC and CEP play a role in cancer progression and metastasis in different animal models. At the clinical level, emerging data support that CEC and CEP kinetics and viability might predict the efficacy on anticancer drug combinations that include antiangiogenic agents. On the basis of these observations, CEC and CEP measurements have attractive potential diagnostic and therapeutic applications for malignant diseases.
Keywords: Angiogenesis, vasculogenesis, endothelial cells, endothelial progenitors, tumor, cancer
Current Pharmaceutical Design
Title: The Circulating Endothelial Cell in Cancer: Towards Marker and Target Identification
Volume: 14 Issue: 36
Author(s): I. Martin-Padura and F. Bertolini
Affiliation:
Keywords: Angiogenesis, vasculogenesis, endothelial cells, endothelial progenitors, tumor, cancer
Abstract: Circulating endothelial cell (CEC) and progenitor (CEP) number and viability are modulated in various pathological conditions including cancer. There is increasing evidence showing that CEC and CEP play a role in cancer progression and metastasis in different animal models. At the clinical level, emerging data support that CEC and CEP kinetics and viability might predict the efficacy on anticancer drug combinations that include antiangiogenic agents. On the basis of these observations, CEC and CEP measurements have attractive potential diagnostic and therapeutic applications for malignant diseases.
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Cite this article as:
Martin-Padura I. and Bertolini F., The Circulating Endothelial Cell in Cancer: Towards Marker and Target Identification, Current Pharmaceutical Design 2008; 14 (36) . https://dx.doi.org/10.2174/138161208786898635
DOI https://dx.doi.org/10.2174/138161208786898635 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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