Abstract
Proper control of cell cycle progression requires the functionality of a small family of activating phosphatases termed Cdc25, which have been implicated in cancer and Alzheimers disease. These protein tyrosine phosphatases are therefore recognized as attractive molecular targets for small molecules. We review the rationale, approaches, progress and challenges for developing small molecule inhibitors of the Cdc25 family. A number of potential chemical probes are discussed and their characteristics are summarized.
Keywords: Protein tyrosine phosphatase, natural products, enzyme assays, reactive oxygen species
Anti-Cancer Agents in Medicinal Chemistry
Title: Is Cdc25 a Druggable Target?
Volume: 8 Issue: 8
Author(s): John S. Lazo and Peter Wipf
Affiliation:
Keywords: Protein tyrosine phosphatase, natural products, enzyme assays, reactive oxygen species
Abstract: Proper control of cell cycle progression requires the functionality of a small family of activating phosphatases termed Cdc25, which have been implicated in cancer and Alzheimers disease. These protein tyrosine phosphatases are therefore recognized as attractive molecular targets for small molecules. We review the rationale, approaches, progress and challenges for developing small molecule inhibitors of the Cdc25 family. A number of potential chemical probes are discussed and their characteristics are summarized.
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Cite this article as:
Lazo S. John and Wipf Peter, Is Cdc25 a Druggable Target?, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (8) . https://dx.doi.org/10.2174/187152008786847738
DOI https://dx.doi.org/10.2174/187152008786847738 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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