Abstract
Extensive use of certain drugs, changes in lifestyles and food habits, as well as stress factors in modern human lives have led to an exponential increase in the incidence of gastric ulceration. The ideal anti-ulcer drug with less side effects and recurrence, and affordability has so far remains elusive, providing avenues for innovation, especially with phytochemicals. This review furnishes extensive information on the earlier works carried out in this area and rationalizes the mode of action of them, citing limitations of the previous studies. The primary aim was to cover different classes of potent natural compounds that have impressive gastro-protective property against various ulcerogens (except Helicobacter pylori infection), and are available in large quantities from the natural sorces. A few examples of synthetic congeners have also been included to highlight the type of innovation that may be required for developing new drugs.
Keywords: Natural Antiulcerogenic Agents, gastric ulceration, natural sorces, Genesis And Therapy, cytokines, anti-inflammatory drugs
Current Bioactive Compounds
Title: Natural Antiulcerogenic Agents: An Overview
Volume: 4 Issue: 4
Author(s): B. Maity and S. Chattopadhyay
Affiliation:
Keywords: Natural Antiulcerogenic Agents, gastric ulceration, natural sorces, Genesis And Therapy, cytokines, anti-inflammatory drugs
Abstract: Extensive use of certain drugs, changes in lifestyles and food habits, as well as stress factors in modern human lives have led to an exponential increase in the incidence of gastric ulceration. The ideal anti-ulcer drug with less side effects and recurrence, and affordability has so far remains elusive, providing avenues for innovation, especially with phytochemicals. This review furnishes extensive information on the earlier works carried out in this area and rationalizes the mode of action of them, citing limitations of the previous studies. The primary aim was to cover different classes of potent natural compounds that have impressive gastro-protective property against various ulcerogens (except Helicobacter pylori infection), and are available in large quantities from the natural sorces. A few examples of synthetic congeners have also been included to highlight the type of innovation that may be required for developing new drugs.
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Cite this article as:
Maity B. and Chattopadhyay S., Natural Antiulcerogenic Agents: An Overview, Current Bioactive Compounds 2008; 4 (4) . https://dx.doi.org/10.2174/157340708786847889
DOI https://dx.doi.org/10.2174/157340708786847889 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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