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Current Gene Therapy

Editor-in-Chief

ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

Applications of Lentiviral Vectors for shRNA Delivery and Transgenesis

Author(s): Oded Singer and Inder M. Verma

Volume 8, Issue 6, 2008

Page: [483 - 488] Pages: 6

DOI: 10.2174/156652308786848067

Price: $65

Abstract

Lentiviral vectors are potent gene delivery vehicles that enable stable expression of transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors expressing small hairpin RNAs generates a system that can be used to down regulate specific target genes in vivo and in vitro. In this review, we will discuss two examples of in vivo applications for the use of lentiviral vectors expressing shRNAs: Gene therapy of neurological disorders and generation of transgenic knockdown animals.

Keywords: Lentiviral Vectors, Transgenesis, RNAs, Gene therapy, neurological disorders

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