Receptor Binding Ligands to Image Infection

Author(s): M. Chianelli, O. C. Boerman, G. Malviya, F. Galli, W. J.G. Oyen, A. Signore

Journal Name: Current Pharmaceutical Design

Volume 14 , Issue 31 , 2008

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Abstract:

The current gold standard for imaging infection is radiolabeled white blood cells. For reasons of safety, simplicity and cost, it would be desirable to have a receptor-specific ligand that could be used for imaging infection and that would allow a differential diagnosis between sterile and septic inflammatory processes. Ligands tested for this purpose include labeled peptides ( Tc-labeled f-Met-Leu-Phe, I-IL-1ra, Tc-IL-8, Tc-P483H, Tc-P1827DS, Tc-C5ades- Arg, Tc-RP517, 111In-DPC11870-11), human polyclonal antibodies, monoclonal antibodies, antibody fragments, antimicrobial agents (ciprofloxacin, sparfloxacin, ceftizoxime, isoniazid, ethambutol, fluconazole, all labeled with 9 Tc), antimicrobial peptides and bacteriophages. Radiolabeled antibodies represent a valid alternative to labeled white blood cells under specific conditions and indications. Radiolabeled antibiotics and antimicrobial peptides are promising candidates for an infection-specific radiopharmaceutical. However, at present we still need to investigate many basic aspects to better understand the mechanisms of binding and accumulation of this class of radiopharmaceuticals to bacteria.

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Article Details

VOLUME: 14
ISSUE: 31
Year: 2008
Page: [3316 - 3325]
Pages: 10
DOI: 10.2174/138161208786549416
Price: $65

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