Abstract
Colorectal and pancreatic cancer represent two major health concerns in their own right – the first for being one of the most prevalent cancers in the western world, and the latter for being one of the most lethal of all human cancers. While progress has been made in cancer research and tumor understanding in general, and for colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) in particular, still thousands of lives are lost to these two diseases annually. Obviously, the search for new molecular markers and pathways that will lead to better and earlier diagnostics, with potential for better and more efficient therapeutic interventions is direly needed. A general overview of cancer hallmarks, with focus on proliferation and apoptosis is given in this mini-review. The molecular role of the telomere function and the universal tumor-antigen survivin, with regards to CRC and PDAC progression and development is discussed. These two markers may hold universal cancer therapeutic potential, also for CRC and PDAC.
Keywords: Colorectal cancer, telomerase, surviving, apoptosis, cell proliferation, therapy, biomarkers
Current Cancer Therapy Reviews
Title: Telomerase and Survivin in Colorectal and Pancreatic Cancer – Biomarkers of Life and Death in the Balance Between Proliferation and Apoptosis
Volume: 4 Issue: 4
Author(s): Kjetil Soreide
Affiliation:
Keywords: Colorectal cancer, telomerase, surviving, apoptosis, cell proliferation, therapy, biomarkers
Abstract: Colorectal and pancreatic cancer represent two major health concerns in their own right – the first for being one of the most prevalent cancers in the western world, and the latter for being one of the most lethal of all human cancers. While progress has been made in cancer research and tumor understanding in general, and for colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) in particular, still thousands of lives are lost to these two diseases annually. Obviously, the search for new molecular markers and pathways that will lead to better and earlier diagnostics, with potential for better and more efficient therapeutic interventions is direly needed. A general overview of cancer hallmarks, with focus on proliferation and apoptosis is given in this mini-review. The molecular role of the telomere function and the universal tumor-antigen survivin, with regards to CRC and PDAC progression and development is discussed. These two markers may hold universal cancer therapeutic potential, also for CRC and PDAC.
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Soreide Kjetil, Telomerase and Survivin in Colorectal and Pancreatic Cancer – Biomarkers of Life and Death in the Balance Between Proliferation and Apoptosis, Current Cancer Therapy Reviews 2008; 4 (4) . https://dx.doi.org/10.2174/157339408786413353
DOI https://dx.doi.org/10.2174/157339408786413353 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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