Titanium and Zirconium Mediated or Catalyzed Umpolung Reactions

Author(s): Hairong Guan

Journal Name: Current Organic Chemistry

Volume 12 , Issue 16 , 2008

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This review presents current strategies of using titanium and zirconium reagents to achieve umpolung of carbonyl and imine functionalities. The reactions of organometallic compounds, including those that are equivalent to acyl anions, α-amino carbanions, α-hydroxy carbanions, and homoenolates, are among the most powerful methods to form carbon-carbon bonds. The remarkable chemoselectivity, regioselectivity, and stereoselectivity observed in many cases once more demonstrate great synthetic application of organotitanium and organozirconium compounds.

Keywords: reagents, titanium, zirconium, Umpolung Reactions, organometallic compounds, chemoselectivity, stereoselectivity

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Article Details

Year: 2008
Page: [1406 - 1430]
Pages: 25
DOI: 10.2174/138527208786241529
Price: $58

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