Title: Protein Kinase CK2 Inhibitors: Emerging Anticancer Therapeutic Agents?
VOLUME: 8 ISSUE: 7
Author(s):Andrea Bortolato, Giorgio Cozza and Stefano Moro
Affiliation:Molecular Modeling Section (MMS), Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, I-35131 Padova, Italy.
Keywords:Protein kinase CK2, casein kinase 2, anticancer drugs, drug discovery
Abstract: Protein kinase CK2 is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. A number of structurally unrelated CK2 inhibitors, tested on a variety of cells derived from tumours, including lymphomas, leukaemias, multiple myeloma and prostate carcinoma, display a proapoptotic effect which is roughly proportional to their in vitro inhibitory potency. In the present review we summarize the most recent discovery of potent and selective CK2 inhibitors and their prospective as future anticancer agents.
