Abstract
Laryngeal cancer is a common head and neck cancer. Despite advances in treatment, improvement in survival and quality of life of patients still remains a challenge. Chemotherapy has become more and more important since this treatment is able to preserve laryngeal function. There is increasing evidence showing that many chemotherapeutic agents kill laryngeal tumor cells via apoptotic mechanisms. The balance between anti-apoptotic molecules and pro-apoptotic ones plays a critical role in determining the sensitivity of the tumor cells to chemotherapy. The commonly used chemotherapeutic agents for laryngeal cancer include cisplatin, 5-fluorouracil and paclitaxel. These three agents may target common apoptotic molecules, but more importantly they have their own particular targets. Systemically analysis of these targets will not only help to optimize the treatment but also provide a rationale for the best combination of two or more agents for the chemotherapy of laryngeal cancer.
Keywords: Laryngeal cancer, apoptosis, cisplatin, 5-fluorouracil, paclitaxel
Current Drug Targets
Title: Chemotherapy for Laryngeal Cancer - An Apoptotic Approach
Volume: 9 Issue: 10
Author(s): Han Ching Liu, George G. Chen, Alexander C. Vlantis, Michael C.F. Tong and C. Andrew van Hasselt
Affiliation:
Keywords: Laryngeal cancer, apoptosis, cisplatin, 5-fluorouracil, paclitaxel
Abstract: Laryngeal cancer is a common head and neck cancer. Despite advances in treatment, improvement in survival and quality of life of patients still remains a challenge. Chemotherapy has become more and more important since this treatment is able to preserve laryngeal function. There is increasing evidence showing that many chemotherapeutic agents kill laryngeal tumor cells via apoptotic mechanisms. The balance between anti-apoptotic molecules and pro-apoptotic ones plays a critical role in determining the sensitivity of the tumor cells to chemotherapy. The commonly used chemotherapeutic agents for laryngeal cancer include cisplatin, 5-fluorouracil and paclitaxel. These three agents may target common apoptotic molecules, but more importantly they have their own particular targets. Systemically analysis of these targets will not only help to optimize the treatment but also provide a rationale for the best combination of two or more agents for the chemotherapy of laryngeal cancer.
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Cite this article as:
Liu Ching Han, Chen G. George, Vlantis C. Alexander, Tong C.F. Michael and van Hasselt Andrew C., Chemotherapy for Laryngeal Cancer - An Apoptotic Approach, Current Drug Targets 2008; 9 (10) . https://dx.doi.org/10.2174/138945008785909257
DOI https://dx.doi.org/10.2174/138945008785909257 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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