Potential Lithium and Fluoride Interactions in Studies of Glycogen Synthase Kinase-3

Author(s): Anna Strunecka, Jiri Patocka

Journal Name: Current Enzyme Inhibition

Volume 4 , Issue 3 , 2008

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The discoveries of the pluripotent role of glycogen synthase kinase-3 (GSK-3) are pointing to GSK-3 as a potential target for therapy of neurodegenerative disorders and type 2 diabetes. GSK-3 is a constitutively active protein kinase that is inhibited in response to various extracellular signals. Lithium has been found to be an important inhibitor of GSK-3 activity and its use as a laboratory tool has contributed to the understanding of the role of GSK-3. Fluoride has been often used in study designs on GSK-3 as the inhibitor of protein phosphatases. Potential interactions of fluoride with the observed lithium effects are discussed.

Keywords: Glycogen synthase kinase-3 (GSK-3), lithium, fluoride, aluminofluoride complexes, protein phosphatase -1

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Article Details

Year: 2008
Page: [93 - 99]
Pages: 7
DOI: 10.2174/157340808785909394
Price: $65

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